Comnoz gave Fullauto the advice to try a different air jet.
This is interesting because as far as I can see, most people who use Mikunis don't even know there is one, let alone change it from the size that most 32 to 36 Mikunis seem to be supplied with. What I have been able to read so far says that the air jet has an effect in combination with the main jet at WOT, and that incorrect sizing can cause weakening or enrichment at the revs built toward maximum rpm.
Have a few thoughts to pass along on the air correction circuit that might clarify a little more about its function.
When an engine is operated under load, the carburetor should deliver a constant fuel/air ratio to the engine, regardless of the engine speed (air speed through the carburetor). To achieve a constant fuel/air ratio, carburetors employ an air correction circuit as part of the main circuit, or so-called high speed circuit. The air correction circuit is a fine tuning feature of the main circuit whereas the main jet is a coarse tuning feature of the main circuit. The fundamental physics underlying the need for air correction of the main circuit are the following.
The pressure drop in the venturi is not linearly proportional to the air flow through the venturi, i.e., the pressure in the venturi decreases at a higher rate than the air flow increases. This causes the fuel/air ratio to increase disproportionately with increasing air flow and results in mixture strength becoming increasingly richer with increasing air speed.
The purpose of air correction in the main circuit is to compensate for this non-linearity that exists between air speed and pressure in the venturi. The air correction feature of the main circuit typically introduces air into an annular area surrounding the main nozzle, which in turn proportionately dilutes the fuel/air mixture to maintain the desired mixture strength under all air flow regimes.
Air from the air correction circuit is commonly introduced to the main nozzle by 2 different means. The 1st means, as shown in Figure 1 (from the Two-stroke Tuners Handbook), involves delivering air directly from the air correction circuit to a region near the top of the main nozzle, where it enters an annular area surrounding the main nozzle and "dilutes" the main nozzle discharge to correct the fuel/air ratio (this is typical on smaller Mikuni VM round slide carbs). The 2nd means of introducing air from the air correction circuit to the main nozzle is shown in Figure 2 (from the Two-stroke Tuners Handbook), where air is introduced to the main nozzle well and fed, via emulsion holes in the main nozzle, into the liquid fuel to dilute it with air. As air speed through the venturi increases, causing "air correction" flow to likewise increase, the fuel level in the main nozzle well decreases, revealing more emulsion holes and introducing more air to maintain a constant fuel/air ratio. This 2nd design has the added benefit of assisting in emulsifying the fuel/air charge by breaking the surface tension of the fuel and aerating it via the tiny streams of air entering the fuel through the emulsion holes.
A wide variety of emulsion tubes having various hole patterns and hole sizes are employed by tuners to provide proper fuel/air mixtures for any engine, regardless of the configuration or modifications performed on said engine. On some carburetors the diameter of the air correction inlet orifice is fixed, but on more sophisticated carburetors, air correction jets are provided in a variety of sizes, much like main jets.
Myriad main nozzle designs can be viewed at the following link.
http://tinyurl.com/cxyq4yv
Regarding the misfire you encounter at high engine speed under only the highest load (top gear), sounds probable that it could be lean back-firing. Might a slightly larger main jet resolve the issue, especially in light of your comment that the main might be on the small side (relative to the book recommendation)? In the alternative, a smaller air correction jet would slightly enrichen as well as delay full recruitment of the main circuit. After all, the air correction jet is simply a controlled air bleed we introduce to the main circuit.
edit - change backfiring to misfire
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