Not really that easy at all: The barrels fasten to the crankcase in a different pattern due to through bolts from the top deck, and the head bolt pattern changes as a consequence as well.
This is a 30,000' summary - I am sure others will fill in more details.
Whether you could resize a set of 750 sleeves/barrels to take a set of 850 pistons is maybe a better approach, but I am not sure of the feasibility of that.
Bigger question would be why would you want to? A good working 750 is no slouch...
Why has nobody pointed out the error here?
The barrels do not 'fasten to the crankcase in a different pattern due to through bolts from the top deck'. I assume top deck means barrel to head mating face?
But anyway, the barrels fasten with exactly the same pattern to the crankcases, 750 or 850! The through bolts use the threaded holes in the crankcases previously used by the 750 base studs!
(on some 750 engines you may need to gouge out some metal from the crankcase mouth, but not all. And it doesn't need to be that pretty!)
However, the head bolt pattern is of course different. That is not insurmountable, Steve Maney used to prefer 750 heads as a base for his porting work and moved the outer 4 bolt holes from 750 to 850 pattern using inserts!
Or you can use an 850 head.
So, theoretically, the job can be done with just new barrels and pistons.
Historically, I went the other way once and fitted a '72 750 top end on a MKIII bottom end for a weekend whilst I was having the 850 head fixed!.
Today, I run a 750 short stroke, so the barrels and head are 850 anyway, to go 850 I 'only' need to change the crank! But because I use JSM rods and pistons, I would also need some more rods.