I think the oxygen sensor on bikes with FI, compensates for changes in the weather. With carbs, if you get them tuned to deliver the max., they sometimes become weather dependent. It seems to happen more with two-strokes, but my thinking goes back a bit. The older four-strokes were probably all running too rich. To get a two-stroke to be really quick, you always had to lean them off to the limit.
To me, getting a four-stroke race bike going quick on petrol, is as difficult as getting a two-stroke race bike going quick on methanol. But I know which is quicker. Two-strokes on methanol are ridiculous.