I have never had any problems with vibrations in the 40 years of owning my Norton and even after converting it to the Featherbed frame back in 1980, but I did get my crank balanced for the Featherbed frame, I can ride all day without any problems, as for reliability in my 40 years of riding my bike has only let me down once and that was a broken chain, the chain had well over 30,000 miles on it and it was the joining link that it lost, if you ride all the time and do the maintenance when needed these motors will keep going, I also ride my bikes hard, I think when they sit for long periods of time thats when you have problems, yes things do wear out but thats part of the maintenance to look for things that have wear in them and replace or fix before they give up, my motor/gearbox have well over 140,000 miles on them with just 1 rebore on the motor.
So I don't understand why some think these are unreliable, but I have modenized my Norton in the last 5 years with better brakes, frontend internals, ingition etc where the 40 year old parts just wasn't up to it no more.
There are a lot more I could do to my bike with JS engine parts but its well out of my budget, but there are a lot of things you can do to these Nortons without a big budget, I have always worked on my bike with a shoe string budget and it works for me.
Ashley