The simple answer is yes, there were differences. Somewhere in the 1972 -1973 years the crankcase changed from the earlier style, most easily identified by the plate on the back of the timing side half, to the final style with breather tube in the back of the timing side case. The parts book lists the newer style from serial number 212278 on. Somewhere in here was also the infamous case with the breather at the bottom rear of the crankcase, and no large drain plug at the bottom, but I'm not sure of the dates for it. There were at least four different 750 crankcase designs between 1969 and 1973. I'm sure LAB probably has more detailed info on this question.
Ken